Frequently Asked Questions

Exosomes, or extracellular vesicles, represent a new non-invasive addition to the regenerative aesthetic toolbox. These nano-sized vesicles contain bioactive cargo with crucial roles in intercellular communication.

Exosome technology, while still in its infancy, is now leveraged in regenerative aesthetic medicine due to its multifaceted role in targeting root causes of skin aging and improving overall tissue homeostasis. The main considerations for practice utilization include variation in exosome purification, isolation, storage, scalability and reproducibility.

Topical exosomes, although variable in source and method of isolation, are generally considered safe in humans on intact skin. The current published research literature does not yet provide a clear consensus on long-term use for skin rejuvenation or hair restoration, nor does it delineate which patients would benefit most from this technology. There are no currently US FDA-approved exosome products on the market for medical indications.

At Exotop, we prioritize transparency and precision in our sourcing methods, particularly when it comes to harvesting exosomes from Adipose-Derived Stem Cells, Edelweiss, and Skin Lactobacillus.

For Adipose-Derived Stem Cell Exosomes, our process begins with the isolation of stem cells from adipose tissue. These stem cells are then cultured under controlled conditions, encouraging the secretion of exosomes. Through a meticulous extraction process, we harvest these exosomes, ensuring their purity and efficacy in promoting skin regeneration and vitality.

Similarly, our Edelweiss-Derived Exosomes are obtained through a carefully curated process that involves the extraction of exosomes from Edelweiss plant cells. Known for their antioxidant properties, these exosomes play a crucial role in protecting the skin from oxidative stress and premature aging.

Finally, our Skin Lactobacillus-Derived Exosomes are sourced from probiotic bacteria naturally found on the skin. Through a specialized fermentation process, we extract and purify these exosomes, preserving their beneficial effects on the skin's microbiome and overall health.

No, neither.

At Exotop, we prioritize transparency and precision in our sourcing methods, particularly when it comes to harvesting exosomes from Adipose-Derived Stem Cells, Edelweiss, and Skin Lactobacillus.

For Adipose-Derived Stem Cell Exosomes, our process begins with the isolation of stem cells from adipose tissue. These stem cells are then cultured under controlled conditions, encouraging the secretion of exosomes. Through a meticulous extraction process, we harvest these exosomes, ensuring their purity and efficacy in promoting skin regeneration and vitality.

Similarly, our Edelweiss-Derived Exosomes are obtained through a carefully curated process that involves the extraction of exosomes from Edelweiss plant cells. Known for their antioxidant properties, these exosomes play a crucial role in protecting the skin from oxidative stress and premature aging.

Finally, our Skin Lactobacillus-Derived Exosomes are sourced from probiotic bacteria naturally found on the skin. Through a specialized fermentation process, we extract and purify these exosomes, preserving their beneficial effects on the skin's microbiome and overall health.

Plant stem cells are undifferentiated cells that can communicate with other plant cells to grow or regenerate all parts of a botanical.

Plant stem cells do not produce signals that can communicate with human cells, and human cells do not have receptors for plant biochemicals. Because they cannot communicate with each other, plant stem cells are unable to influence human cellular activity or stimulate a direct cellular response to grow new tissue, such as collagen. Plant stem cells act as antioxidants in skincare products, and—like many antioxidants commercially available—can offer an anti-inflammatory effect, protect against UV-induced oxidative stress, and can nourish skin cells. The American Academy of Dermatology has outlined the role plant stem cells play in skincare. https://www.aad.org/media/news-releases/new-technology-could-make-antioxidants-in-skin-care-products-more-effective

Conditioned media is the blend of nutrients that remain after filtering cells for unwanted materials.

Very few ingredients are able to reach the dermis where stem cells reside to activate them. However, irritation will trigger an immune response in the body that will activate stem cells to identify damage and migrate to injured areas to begin reparative cellular activity. This means that any pro-inflammatory ingredient that irritates skin or induces an allergic reaction could be considered a stem cell activator because stem cells in skin are a defense mechanism that detects damage and responds by migrating to injured cells and creating healing cytokines, growth factors, and mRNAs.

Growth factors are subset of cytokines with extracellular polypeptide proteins found in a variety of cellular processes, such cell growth and migration, and are integral in wound repair.

Inflammatory cytokines may be helpful to begin the injury repair process, but you want to quickly transition from inflammatory to anti-inflammatory (the so-called regenerative phase of wound healing). If you stay in an inflammatory state for prolonged periods, you may get scars, rigid fibroblasts, poor cross linking on collagen fibers, high levels of proteases, which accelerates the appearance of aging rather than being anti-aging. In microneedling treatments, the needles that penetrate the skin induce an inflammatory response that will generate pro-inflammatory cytokines, so there is no need to add more. However, healing duration will be shorter with additional anti-inflammatory cytokines.

Stem cell cytokines and growth factors (GF cytokines) are signaling molecules produced by stem cells and other cells in the body. These molecules play essential roles in cell communication, proliferation, differentiation, and tissue repair processes.

Stem cell cytokines are secreted by stem cells and serve as signaling molecules to regulate various cellular functions. They can influence neighboring cells to differentiate into specific cell types, promote tissue regeneration, modulate the immune response, and regulate inflammation.

Growth factors (GF cytokines) are a subset of cytokines that specifically stimulate cell growth, proliferation, and differentiation. They play crucial roles in tissue development, wound healing, and maintaining tissue homeostasis. Growth factors can also influence cell migration and angiogenesis (the formation of new blood vessels).

In skincare, stem cell cytokines and growth factors are often used in formulations to promote skin rejuvenation, collagen production, and overall skin health. They can help reduce the appearance of fine lines and wrinkles, improve skin texture and elasticity, and enhance the skin's natural regeneration processes.

Many clients are told by physicians or aestheticians that stem cells are too large to reach the dermis. Although a stem cell may be too large, Exotop contains only the cytokines and growth factors that are extracted from stem cells, and uses liposomonal technology to ensure that these microscopic molecules can slip between epidermal cells to reach skin repairing cells. We wrap all our GF & cytokine proteins in lipid envelopes (nano-liposomes), and add other penetration enhancers and autocrine amplifiers.

Growth factors derived from humans can be used during microneedling because they are biogenic and will not cause an allergic reaction. They are a byproduct of cellular conditioned media, and neither contain nor transmit DNA or diseases.

Epidermal growth factor (EGF) is a family of cytokines involved in the growth, development, and healing of damaged or dead tissues. There are several EGFs that reside in the dermis and are triggered later in the skin regeneration process. However, topically applied EGFs can induce the outer or epidermal layer of skin cells to multiply and thicken the skin.

Bio-identical growth factors are proteins that have been combined to create a molecular structure that is identical to what is found in human sources and have the same effect. Some recombinant growth factors are included in Exotop to supplement the broad range of biologic proteins found in humans. However, there are only a few commercially and economically available, and therefore do not fully replicate the blend that can be sourced in bone marrow stem cells.

For skin the most important cytokines (actually families of cytokines, each with multiple members) are epidermal growth factor (EGF) family, transforming growth factor beta (TGF-beta) family, fibroblast growth factor (FGF) family, vascular endothelial growth factor (VEGF), granulocyte macrophage colony stimulating factor (GM-CSF), platelet-derived growth factor (PDGF), connective tissue growth factor (CTGF), interleukin (IL) family, and tumor necrosis factor-alpha family.

Some results take time to achieve, and others happen quite fast. Some users see results in as little as 4 days. Typically, most people see noticeable results within 30 days. Most importantly, you’re preventing new visible signs of aging every day when you use Exotop.

We feel confident our customers will see results with our product and we offer a guarantee on any purchase made from Exotop.com. If you are not satisfied with our products, you may return them for a full refund, within 30 days after purchase.

Purchases made from Exotop providers are subject to the return policy of the provider, and may not fall under our 30 day guarantee.

To arrange for a product return for an order made on Exotop.com, feel free to call our customer service department at (###) ###-####, or email [email protected]. We reserve the right to limit returns to one per household.

Yes, we ship to most places around the world, with the exception of the United Arab Emirates and Saudi Arabia. Shipping costs apply for international orders, and will be added at checkout. We run discounts and promotions all year, so stay tuned for exclusive deals.

It depends on where you are. Domestic orders generally take 5-7 business days to arrive. Overseas deliveries can take anywhere from 7-16 days. Delivery details will be provided in your confirmation email.

We use primarily FedEx and UPS, and local courier partners internationally. You’ll be asked to select a delivery method during checkout.